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Constipation is the longest-lasting side effect, lasting an average of 67 weeks

Constipation may develop due to slowed gastric motility

Caution is also warranted when dismissing smaller quantitative sex differences in the therapeutic or adverse effect outcomes, especially considering the staggeringly large numbers of patients taking GLP-1-based therapeutics

I created GSLIM, a natural supplement that enhances GLP-1 production using ingredients like lemon extract, red orange extract, saffron and turmeric

The tolerability profile is dominated by GI adverse events at higher rates than earlier-generation GLP-1s, with higher dropout at 12 mg than at 9 mg

TLDR: This thread discusses the use of GLP-1 agonists for weight loss and whether some individuals naturally have higher levels of GLP-1, which might make them less prone to overeating and diabetes