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The review further distinguishes between established outcome benefits (CVD, CKD, and OSA) and conditions still under investigation (neurodegeneration, arthritis, and some liver endpoints)

Activation of GLP-1 receptor promotes bone marrow stromal cell osteogenic differentiation through -catenin

[20] [21] These medications amplify these physiological effects by binding to GLP-1 receptors throughout the body, including in the pancreas, gastrointestinal tract, and brain regions that control appetite and satiety

GLP-1 agonists are not a substitute for insulin

Current studies are still largely in the preclinical or early clinical phases, and larger trials involving human subjects are necessary to confirm the safety and efficacy of these drugs for addiction treatment