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Zhang Q, Li Q, Liu S, Zheng H, Ji L, Yi N et al (2022) Glucagon-like peptide-1 receptor agonist attenuates diabetic neuropathic pain via inhibition of NOD-like receptor protein 3 inflammasome in brain microglia

GLP-1 medications are not approved as a replacement for insulin in type 1 diabetes

10.1210/jc.86.9.4047 J

With Bydureons remarkable profile (nearly two points in A1c reduction, weight loss, much less nausea than Byetta, convenience of a once-weekly shot), we would have thought at least the FDA could have approved the drug in a population that did not include individuals with impaired renal systems, assuming this is the population in question

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.FDA Approves New Drug Treatment for Chronic Weight Management [ 3.ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al

The construct and various mutants of human GIPR were cloned into pcDNA3.1 vector for cAMP accumulation and whole-cell binding assays
