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Description
Clinical trials are expected to start in the second half of 2023, with topline data due in 2024

In contrast, the effect on cardiovascular death did not reach at the statistical significance (HR 0.82, 95% CI 0.571.16), possibly due to lower event rate

When you consider that roughly three-quarters of American adults are overweight or obese, employers could be faced with hundreds or even thousands of GLP-1 bills each month

An analysis published this week in JAMA Internal Medicine found that most participants in a clinical trial who were assigned to stop taking tirzepatide (Zepbound from Eli Lilly) not only regained significant amounts of the weight they had lost on the drug, but they also saw their cardiovascular and metabolic improvements slip away
Endocrinology 153: 3054-3065, 2012

Preclinical and clinical studies have shown that these drugs can decrease hepatic steatosis, or fat accumulation in the liver, which is a hallmark of MASH1
