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Sigalet DL, de Heuvel E, Wallace L, Bulloch E, Turner J, Wales PW, et al

In our study, we observed a modest improvement or slight reduction in cardiac hypertrophy in MC4R KO mice treated with GLP-1 analogs, which further supports the notion that these drugs have potential cardiovascular benefits

Furthermore, the activation of the GIP receptor also improved glucose metabolism in diet-induced obese mice without changing body weight or fat mass [69]

Previous studies suggested that both PKC activation and increased intracellular Ca 2+ levels are required for TRPM5 activation [24]

"Novo Nordisk A/S: Wegovy pill approved in the US as first oral GLP-1 for weight management" (Press release)

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