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Pool of Seven Controlled Clinical Trials Adverse reactions were also evaluated in a larger pool of adult patients with type 2 diabetes mellitus participating in seven controlled clinical trials which included two placebo-controlled trials (SURPASS-1 and -5), three trials of MOUNJARO in combination with metformin, sulfonylureas, and/or SGLT2 Inhibitors (SURPASS-2, -3, -4) [see Clinical Studies (14.3)] and two additional trials conducted in Japan

Glycemic control deterioration occurs in patients with type 2 diabetes

Future directions and research gaps Although GLP-1 therapies have revolutionized obesity and diabetes management, important knowledge gaps remain in optimizing their long-term safety, tolerability, and body composition outcomes

Theyve complained about stomach issues and not being able to enjoy things they used to, like wine and coffee

While it is highly effective at managing blood sugar, it is not a cure for diabetes and is not intended for use in people with type 1 diabetes