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Effects of the switch from dulaglutide to tirzepatide on glycemic control, body weight, and fatty liver: a retrospective study

GLP-1 constipation results from the drug's effect on gut motility, by slowing gastric emptying and intestinal transit, stool moves more slowly through the colon, allowing more water absorption and producing harder, less frequent bowel movements

In this study, our hypothesis is that the increase in intestinal NE associated with sympathetic nervous system activation will play an important role in the association between the gut bacterium, especially E

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