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This blog is part of an ongoing series on A Brave New World: Therapeutic Area Deep Dives

In recent years, many payers have taken steps to limit the costs of GLP-1s and introduced limits to coverage for the use of these products for weight loss.
While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives
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