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Patients with type 2 diabetes have an impaired insulin response to GLP-1 that is believed to be secondary to reduced post-prandial GLP-1 secretion [60]
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The increased internalization of exendin-asp3 vs

Notably, GRP regulation of glucose handling is not fully dependent on GLP-1 signaling, because GRP also directly stimulates insulin secretion in the isolated perfused dog pancreas [340] and further delays gastric emptying [341,342]