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Results Glutamine was a more potent GLP-1 secretagogue than glucose or other amino acids, increasing GLP-1 release 7.10.7-fold ( n =19) at 10 mmol/l, with an estimated median effective concentration of between 0.1 and 1 mmol/l

They are also very expensive, and frequently not covered by insurance

Receptor tolerance is another: sustained GLP-1 stimulation can lead to partial desensitization, reducing the appetite-suppressing effect over time

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However, the short half-life and dose-limited adverse gastrointestinal effects of GLP-1 have limited its clinical application

Medications are prescribed based on what medical providers determine is medically appropriate and necessary for each patient, the company said