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Whether this indicates the induction of low-grade pancreatic inflammation or of membrane leakage leading to more spillover of intracellular (pro)enzymes into the extracellular space or an altered level of expression of digestive enzymes in pancreatic acinar cells will need to be clarified in future studies

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By 24 months, the proportion of patients with ongoing papilledema was lower in the tirzepatide group (RR 0.32, 95% CI 0.1890.542)