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Together, this evidence suggests that GIP may drive WL directly, inhibiting caloric intake, indirectly exploiting the anorectic action of GLP-1, or by reducing GLP-1RA adverse effects (59, 60, 63)

The key principle is titrating to the lowest effective dose that produces consistent, sustainable weight loss of 1-2 pounds per week, while the glycine component provides its protective benefits at a steady state throughout

Tirzepatide is contraindicated in pregnancy based on preclinical safety signals and absence of human data

4.10 SURMOUNT-1: tirzepatide for weight loss in obese adults In the SURMOUNT-1 trial, 2,539 adults with an average weight of 104.8 kg and an average BMI of 38.0 were treated with weekly doses of tirzepatide (5 mg, 10 mg, 15 mg) or placebo for 72 weeks

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