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Common GLP-1 side effects include nausea, vomiting, constipation, and loss of appetitemost mild to moderate and diminishing within 4-8 weeks

Still, this function is tightly regulated by dipeptidyl peptidase-4 (DPP-4), an enzyme that contributes to the rapid hydrolysis and inactivation of incretin hormones, resulting in decreased insulin secretion [3]

Mehta LS, Velarde GP, Lewey J, Sharma G, Bond RM, Navas-Acien A, et al

[1] Plasma donation requires adequate hydration and stable fluid balance

Staying at early doses without physician adjustments may limit progress
