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Shortening this interval increases peak drug concentration and the risk of gastrointestinal side effects

(3) Dose escalation effects and economic impossibility: Compensating for poor absorption primarily increases luminal concentration rather than systemic exposure, causing gastrointestinal class effects and inflating manufacturing costs to prohibitive levels before achieving therapeutic efficacy

doi: 10.2337/diabetes.52.1.124 [DOI] [PubMed] [Google Scholar] 20

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