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Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

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[74] used an apoliprotein-E deficient (ApoE / ) mouse model to show the beneficial effects of liraglutide as they relate to atherosclerotic vascular disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Farrs J., Pujol A., Coma M., Ruiz J.L., Naval J., Mas J.M., Molins A., Fondevila J., Aloy P

These compounds have been associated with multiple health benefits, including potential anti-obesity effects, improvements in metabolism, and supporting overall cardiovascular health