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No impact on bone fractures : If osteoporosis is a concern, the GLP-1 receptor agonists were shown not to increase fracture rates.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Works best with Exercise: A randomized clinical trial found that GLP-1 RAs work best for weight loss when combined with exercise

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Glp1r flox/flox ), the anorexigenic effect of liraglutide was markedly attenuated [1]

Clinical data analysis suggests that metformin use reduces the risk of malignancies by approximately 30% [10] and significantly decreases tumor-related mortality in patients with type 2 diabetes [103]

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Periyalwar, this side effect comes from the way GLP-1s affect the digestive tract
