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Other benefits of ultra-long-acting GLP-1RAs include less fluctuation in blood concentration, improved gastrointestinal tolerance, and a simpler and more convenient once-a-week dosing regimen that improves the compliance of patients and the persistence of treatment (Gentilella et al., 2019)
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The remaining authors declare not conflicts of interest
Alternative satiety hormones such as PYY and NPY2 agonists show medium-to-high activity, with patents from major players [30, 31] and scientific reviews exploring their potential as complements or alternatives to GLP-1 [32]
Obesity is also a major driver of non-communicable diseases such as cardiovascular disease and some cancers
