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While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation
Regarding adverse events, one thing stands out is dysesthesia which occurred in 8.8% and 20.9% (9 mg and 12 mg, respectively) of patients, compared to 0.7% with placebo
Bridging the gap between guidelines and practice will require systemic interventions, including physician training, patient-centered care models, and devising research strategies such as national HF registries to understand and tailor therapeutic approaches from an Indian perspective.
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The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events
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