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Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1Ra) and sodium-glucose cotransporter protein-2 inhibitors (SGLT2i) are currently used in T2DM management

Skin-specific adverse effects were not highlighted as a primary safety signal in that publication, though injection site reactions were noted as expected with subcutaneous administration

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Data were reported from each study within forest plots as the estimated RR with a 95% confidence interval (CI)

These types of data and the difficulty to manufacture a peptide like GLP-1, raise the barriers to entry for the duopolist market leaders