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In crude analyses, GLP-1 receptor agonist use was associated with an increased incidence of suicidality compared with DPP-4 inhibitors (crude incidence rates 3.9 v 1.8 per 1000 person years, respectively

Compared with other second- or third-line glucose-lowering medications, the GLP-1RAs demonstrated a lower rate of adverse CVEs, including heart failure (HR 0.88

Although, in the last 10 years, the use of GLP-1 RAs, especially semaglutide and liraglutide, has increased, its clinical implications and how it affects metabolic parameters have yet to be fully consolidated

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2 GLP-1R monotherapy (e.g., semaglutide) is highly effective, but dual GLP-1R/GIPR agonists (e.g.,

Patients have found compounded semaglutide to be a cheaper, accessible GLP-1, but health experts warn of risks tied to the non-FDA-approved drugs.