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The underlying pharmacological mechanism remains unclear [67]

Colonna said he usually tells patients to ground their expectations, especially at the beginning

How These Medications Work: The Science Behind the Results Semaglutide: The Single-Receptor Approach Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist

Thus, the development of an oral GLP1-RA agent would promote medication adherence and quality of life, further consolidating its beneficial effects in real-life clinical practice

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Lancet 394:131138 Tuttle KR, Lakshmanan MC, Rayner B, Busch RS, Zimmermann AG, Woodward DB et al (2018) Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial