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Because semaglutide slows down digestion, jumping straight to a high dose could cause significant discomfort, such as nausea or stomach upset

Nausea was the most common adverse event (7.8%), and treatment discontinuation occurred in 10.4%, mainly among individuals previously treated with GLP-1 receptor agonists

These effects aid in managing blood sugar levels and promoting weight loss

However, 5 to 10% of patients with prediabetes turn to type 2 DM per year and there is not a pharmacological solution without side effects in the long term

Practical Implications: For magnesium supplements, this could mean that it might take longer for them to become fully absorbed or for their effects to be perceived