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Each subsequent pulse causes the glycemic threshold to be adjusted to a higher level, which ultimately results in the need to modify antidiabetic therapy

doi: 10.1016/j.neuroscience.2010.08.028 218 MaTDuXPickJESuiGBrownleeMKlannE

Mild hypoglycemia was reported by 0, 0.6, and 1.9% of patients receiving vildagliptin 50 mg/day, 100 mg/day, or a placebo, respectively [19]
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