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Tirzepatide incorporates structural modifications, including -aminoisobutyric acid (Aib) residues and a C20 fatty acid side-chain

The SURMOUNT-1 trial reported a 6.2% treatment discontinuation rate in the 15 mg group due to adverse events, compared to 4.3% in the 5 mg group
Through a dual-targeted approach to hormone regulation, Mounjaro addresses key factors involved in blood sugar control and appetite

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The pharmacokinetic rationale is questionable given the 5-day half-life, but some users report better side effect tolerance with split dosing
