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If you are experiencing diarrhea (less common than constipation but it happens), increase even further

Side Effects Both medications have similar side effect profiles, primarily gastrointestinal issues such as nausea and vomiting

The same general technique applies

In the DREAMS-3 trial, Mazdutide showed significantly higher composite metabolic target achievement rates compared with Semaglutide, while also demonstrating advantages in individual glycemic and weight-loss outcomes

These studies consistently demonstrated superior glycemic control compared to placebo and active comparators, including established GLP-1 receptor agonists and insulin therapies

Patients experiencing persistent nausea or vomiting should maintain fluid intake and contact healthcare providers if unable to tolerate oral fluids