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Additionally, the suppression of pro-inflammatory cytokines (e.g., TNF-, IL-6) and inflammatory pathways, including the blocking of NF-B activation [39, 91], contributes to the establishment of an anti-inflammatory environment that can mitigate oxidative stress and inflammation induced muscle protein catabolism, thereby supporting the preservation of SMM and functional capacity [40]

[51] reported decreased food seeking and a reduction in body weight and comorbidities such as obstructive sleep apnea, hypertension, and diabetes mellitus in PWS patients after laparoscopic sleeve gastrectomy

The dual mechanism of action may provide greater resilience against these factors by targeting multiple pathways simultaneously

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