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The involvement of DPP-4 in metabolism of endogenous SDF-1 is compatible with the finding that the truncated metabolite, SDF-1 3-67, was present in wild-type mice, but not in animals lacking DPP-4 (62), with this observation being extended in subsequent studies in mice and Rhesus monkeys (63) and in patients with T2DM (64) showing that levels of SDF-1 3-67 were reduced while those of the intact 1-67 form increased concomitantly when DPP-4 activity was inhibited

These effects are typically transient and subside as the body adjusts to the medication

Pushing the plunger too fast forces the fluid into the tissue rapidly, creating pressure that causes stinging and can lead to lump formation

This dual action may lead to different effects on body weight and blood glucose (sugar)

10.1001/jamanetworkopen.2024.13172 [DOI] [PMC free article] [PubMed] [Google Scholar] 90

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