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Lack of drugdrug interaction was concluded if 90% confidence intervals (CIs) for the ratio of area under the plasma concentrationtime curve (AUC) or maximum concentration (Cmax), with/without oral semaglutide, were within a pre-specified interval (0.801.25)

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Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval