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10.1016/j.obpill.2024.100127 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Nauck MA, Meier JJ (2016) The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

& Wang, Z

JAMA Cardiol 5:11821190 Chilton R, Tikkanen I, Cannon CP, Crowe S, Woerle HJ, Broedl UC, Johansen OE (2015) Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes

These effects were compared to those of untreated controls that were also maintained on a high-fat diet

The molecular modifications result in different pharmacokinetic profiles between short-acting medications like exenatide BID and long-acting weekly treatments such as dulaglutide and semaglutide