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The effect is most noticeable during the active dose-escalation phase and the first few weeks at target dose

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A more acidic or concentrated urinary environment where stones can easily grow

,,WangZ-B,Xin-S-S,L-nD,W-yD,HouY-LLiuC-Qet al.The potential role of probiotics in controlling overweight/obesity and associated metabolic parameters in adults: A systematic review and metaanalysis.2019;20191:3862971 28

However, many experience weight regain and express interest in restarting treatment