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In 2022, the FDA approved Mounjaro, an injection of the drug tirzepatide, and in 2023, it approved the similar drug Zepbound

Interestingly, a comparison of acute metabolic responses with the chronic profiles at the end of the treatment period strongly suggests that while the different GLP1-based agonists may share primary mechanisms of action, the durability and efficiency of their long-term metabolic responses differ, with clear superiority for the GLP1/E compound

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Weaning off tirzepatide gradually while building sustainable habits is one approach