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No impact on bone fractures : If osteoporosis is a concern, the GLP-1 receptor agonists were shown not to increase fracture rates.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Works best with Exercise: A randomized clinical trial found that GLP-1 RAs work best for weight loss when combined with exercise

Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, et al

Mild reactions, such as a Mounjaro injection site itchy feeling, can often be monitored while continuing treatment

These changes typically reflect positive therapeutic effects rather than direct medication side effects

Last reviewed: June 17, 2026 Last updated: June 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

This makes weight loss injections for athletes a practical solution rather than a restrictive one