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Immunofluorescence imaging revealed that FITC-labeled exendin 939 was bound to TRPV1 on the cell surface in CHO K1 cells expressing human TRPV1 but not in nave CHO K1 cells (Fig

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Because thermoneutrality minimizes the contribution of non-shivering thermogenesis to whole-body energy expenditure and because non-shivering thermogenesis requires functional brown adipose tissue (BAT) [775], these data imply a contribution of endogenous GLP-1R signaling to the control of energy expenditure, at least in diet-induced obese mice, by regulating BAT activity