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Description
The least-squares mean percentage weight reduction was 8.7% in the 1-mg group, 16.3% in the 4-mg group with an initial dose of 2 mg, and 17.8% in the 4-mg group with an initial dose of 4 mg
Depending on glycaemic response and tolerability, the dose may be further increased to 1 mg weekly after at least four weeks, with a maximum licensed dose of 2 mg weekly available for those requiring additional glycaemic control after at least four weeks at the 1 mg dose

This method is capable of high rates of conversion to vinegar achieved by improved oxygenation

The TRIUMPH-5 head-to-head trial between retatrutide and tirzepatide is currently ongoing, with primary completion expected in late 2026

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