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CV: cardiovascular The treatment effect for the primary composite endpoint, its components, and other relevant endpoints in Study 1 are shown in Table 6

RMSD analysis was performed in PyMOL

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GLP-1 quantification GLP-1 in the cell supernatant was quantified with a High Sensitivity GLP-1 Active ELISA Kit (EZGLPHS-35K, Merck) according to the manual provided by the manufacturer

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The PlexusDx Precision Peptide Genetic Test analyzes your GLP1R genetic variant (rs6923761) and 13 other peptide-pathway genes to predict your baseline responsiveness to semaglutide