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However, with the publication of the recent ADA guidelines, GLP-1 RAs are now recommended for the first time as an adjunctive therapy to lifestyle interventions for adults with T2D, particularly those who are overweight or obese and have NAFLD/MASLD (Level of evidence B)

Future prospective studies should adopt a more comprehensive methodological approach, including measures of insulin resistance (eg, HOMA-IR), hypoglycemia monitoring, and validated quality-of-life questionnaires, to better reflect the full impact of GLP-1 analogue therapy on patient outcomes

[2] [3] It is licensed in some countries including the United States and Canada for the reduction of excess abdominal fat in adults with HIV-associated lipodystrophy, but any use in the UK would be on an unlicensed basis, typically via a named patient or specials route under specialist supervision

Licensed Weight Management Options In the UK, licensed prescription treatments for eligible adults include Mounjaro (tirzepatide), Wegovy (semaglutide) and Saxenda (liraglutide)

This study suggests that [GLP-1s] may have potential to be a powerful tool to optimize preconception health. The findings were published in the American Journal of Obstetrics and Gynecology

Avoid injecting within 2 inches of your navel, previous injection bruises, or areas with scars or stretch marks