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Glucose stimulates insulin release from pancreatic cells in a biphasic manner

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The MN patch could load up to 2.210.14 mg of liraglutide in a patch size of 0.9 cm2, which was nearly two orders of magnitude higher than that obtained with conventional MN patches of the same size

This becomes especially apparent in the setting of rapid and massive weight loss, as in the case of bariatric surgery