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However, most GLP-1 medications are still under patent protection, limiting competitive pricing pressure

As a result, patients with largely postprandial hyperglycaemia are more likely to benefit from treatment with short-acting GLP1-RAs as opposed to individuals with predominantly fasting hyperglycaemia, who would derive greater benefit from long-acting agents [52]

Half-Life Extension Strategies Apart from DPP-4 enzymolysis, another GLP-1/GIP degradation pathway, renal metabolism, can be overcome by augmenting the drug volume to prolong the half-life

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[23] In contrast, patches only appeared in 2025

To address the extremely short half-life (2 min) of native human GLP-1, structural modifications have been applied to GLP-1 RAs and a dual GLP-1/GIP RA