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A study using fluorescently labeled lipidated analogues of exendin-4 showed that they are distributed in the hypothalamus [56]

However, it is critical to distinguish between biological activity and therapeutic efficacy: these biomarker changes did not translate into any measurable clinical benefit, and should therefore be interpreted as evidence of limited central engagement rather than as support for the prevention-dominant hypothesis

Safety and efficacy of oral semaglutide versus dulaglutide both in combination with one OAD (oral antidiabetic drug) in Japanese subjects with type 2 diabetes (PIONEER10)

S.ChenY.FazioliK.RivaraM

You can always eat again in 2-3 hours if you're actually still hungry
