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The longevity of action of G001 and G002 differed markedly, their half-lives in rats being 25 min and 12 h respectively (unpublished data)

Why Diarrhea May Worsen or Persist After 12 Months Tolerance to nausea and appetite suppression typically improves by month 6, but tolerance to digestive side effects develops unevenly

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The microdosing tirzepatide chart shows that split dosing preserves much of the efficacy because neither receptor requires high peak concentrations for activation

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