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Trials will therefore require structured support slow titration, proactive side-effect management, nutritional and exercise guidance, and caregiver involvement to prevent dilution of efficacy signals

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Bruising after semaglutide shots is a common concern for patients using this glucagon-like peptide-1 (GLP-1) receptor agonist for type 2 diabetes or chronic weight management

doi:10.1177/15598276241246728

In a 24-week casecontrol study of obese patients with T2DM, the liraglutide plus metformin group exhibited reductions in EAT thickness from 9.6 2.0 mm to 6.8 1.5 mm at 12 weeks and 6.2 1.5 mm at 24 weeks, whereas no significant reduction was observed in the metformin-only group [140]

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