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The primary retatrutide literature includes a discovery and preclinical characterization paper in Cell Metabolism (2022), a cryo-electron microscopy structural study in Cell Discovery (2024), a phase 1b multiple-ascending-dose trial in The Lancet (2022), and phase 2 trials reported in the New England Journal of Medicine (2023), The Lancet (2023), and Nature Medicine (2024)

doi: 10.1097/HJH.0b013e328341939d

Petersen KF, et al

Those with Certain Chronic Illnesses: Chronic diseases such as cancer, heart disease, and inflammatory bowel disease (like Crohns disease or ulcerative colitis) can increase the risk of blood clots

Retatrutide's approximately 6-day half-life is what makes once-weekly dosing appropriate

To provide rapid symptomatic relief while the methotrexate takes effect, a bridging therapy of low-dose oral prednisone (5 to 10 mg daily) was prescribed, with a plan to taper off within four to six months (Cohen & Mikuls, 2025)