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Understanding the mechanism, risk factors, and management strategies can help patients make informed treatment decisions with their healthcare provider

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As Healio previously reported from the ACHIEVE-1 trial, orforglipron (Foundayo, Eli Lilly), a small molecule oral GLP-1, conferred greater decreases in HbA1c and body weight at 40 weeks

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In fact, the majority of patients showed stable weight or continued weight loss after their last documented GLP-1RA prescription in the participating health systems.Notably, LLM-enabled curation of clinical notes revealed that patients without weight regain were significantly more likely to have documented exercise counseling after their last prescription, suggesting that continued physical activity may play a role in sustaining weight loss after GLP-1RA discontinuation