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Application (Type 2 Diabetes, Weight Loss)

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Weeks 12-16+: optimization and maintenance Beyond the 12-week mark, the rate of change typically slows as the body reaches a new equilibrium

The notable exception to this is saxagliptin

Testosterone drifts down with age too, but less than the low T epidemic ads imply, and it falls more with weight gain and poor health than with age alone (Wu, New England Journal of Medicine, 2010)

Total T3 levels often decline during caloric restriction as the body downregulates metabolic rate to conserve energy, a process sometimes called "euthyroid sick syndrome" or "low T3 syndrome." Free T3 may remain in the normal range but trend toward the lower end