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This multifaceted action has made GLP-1 receptor agonistsmedications that mimic the effects of endogenous GLP-1valuable therapeutic agents for managing type 2 diabetes and, more recently, obesity

In health, GLP-1 stimulates the synthesis and secretion of insulin from pancreatic -cells in a glucose-dependent manner (i.e., it is activated when blood glucose levels are elevated, typically in the postprandial state)

medication adherence is the most important factor in achieving sustainable results (Polonsky et al., Diabetes Care , 2020)

Gallbladder problems, including gallstones or gallbladder inflammation, have been reported with tirzepatide use

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