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doi:10.1007/bf00401145

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Unfortunately, clinical trials carried out so far have not shown such changes in the human gut, not only because it is difficult to determine the length (ranging from 3 to 8 m) of the small intestine in adults, but also the direct clinical manifestation of reduced intestinal diameter and slow transit is constipation, a common symptom with many causes

Clinical trials have identified higher risks of gastrointestinal (GI) events such as pancreatitis, bowel obstruction, biliary disease, and gastroparesis