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Discussion GLP-1R agonists are promising agents for treating type 2 diabetes mellitus that reduce blood glucose via glucose-dependent insulin secretion with minimized low risk of hypoglycaemia

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Conclusion GLP-1 RAs provide clinically meaningful weight loss primarily through selective fat mass reduction, with relative preservation of lean tissue, supporting their role in achieving quality weight loss

For patients with established HF and a reduced left ventricular ejection fraction (LVEF), the LIVE and FIGHT trials studied the effect of 2-year liraglutide use [90, 91]