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The paper suggests initiating therapy at roughly 1025% of standard starting dose for type 2 diabetes or obesity, which for tirzepatide (approved starting dose 2.5 mg) would be roughly 250625 g, or 0.25 0.625 mg

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Because tirzepatide also acts on the GLP-1 pathway, it slows gastric emptying in much the same way, so the gut side effects tend to look familiar

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