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The optimistic scenario assumes: Higher weight-loss efficacy, based on emerging data from trials of AOMs Expanded access to the drug, driving higher uptake assumptions Higher persistency, driven by reduced costs and oral forms of the drug and fewer side effects Lower weight regain after stopping the drug Higher non-weight-loss-related mortality impacts The pessimistic scenario, conversely, considers lower efficacy, lower uptake assumptions, higher and quicker weight regain, and lower non-weight-loss-related mortality impacts

But like its counterparts, Zepbounds price tag can feel out of reach

Vitamin B12 deficiency is particularly relevant in patients also taking metformin, which can reduce B12 absorption over time

Diabetes has what I would think is a more significant potential for long-term damage

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This targeted approach supports the growing understanding that gut microbiome health plays a meaningful role in long-term metabolic wellness