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Compared to those receiving neither medication, all-cause mortality was significantly lower among patients treated with SGLT2-I only (HR 0.28, 95% CI 0.270.29), GLP-1RA only (HR 0.39, 95% CI 0.370.40) and both agents (HR 0.17, 95% CI 0.160.18)

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Semaglutide was effective in lowering the concentration of low density lipoprotein (0.16 mmol/L (0.30 to 0.02)) and total cholesterol (0.48 mmol/L (0.84 to 0.11))

GLP-1 drugs show modest weight loss (~5%) in breast cancer patients, highlighting potential as supportive therapy.
